I’d recommend looking at separate amp/cab sims for guitar and bass. I really like Kuassa’s sims - Cerberus is a great bass amp sim, and their Orange, Fender and Marshall amp sims are great for guitar. We use them here:
That’s Kuassa Cerberus for the bass amp/cab sim and Kuassa Amplifikation Clarent for the guitar.
This one is using Cerberus for bass and Amplifikation Matchlock (Fender) for guitars:
The SVT-VR sim from PluginAlliance is also a popular good one.
For effects there’s many, many sources to choose from. I like MeldaProduction and Kilohearts for theirs. You know that Reaper comes with many built in as well, right?
We have a plugin-related topic here:
If you want to get started inexpensively, Ignite Amps offers excellent free bass and guitar amp sims, and a cab sim that works for either, standalone: