I think the caveat I would have here is the same as I have with combo amps. Basically, if this amp head is your effects, then you’re out of luck if you want to change amps.
Now, upgrading this amp seems unlikely - it’s a great amp - but you never know.
The really useful thing I see here is (either of) the pair of microtubes effects and the compressor can be used to give this amp a really nice tube-like tone, even without the distortion kicking in.
So it looks like a killer amp to me, but I wouldn’t think of it as replacing pedals, but instead sort of enhancing them by having great drive and tone on the amp.
Same - It sounds like slaving will work for him over there but it seems categorically worse to me in all ways to just using this 500W amp to drive a couple cabs. Is there a reason you want to do this?
One reason I could guess is if you had a dedicated space with an amp and cab already there and didn’t want to lose your effects - and that’s exactly the issue I was describing above, where discrete pedals are a more flexible and attractive option to me.