A fascinating topic, since “we left-handers” are different than most folks. I honestly don’t know if I am truly ambidextrous or not because there’s the training factor. When I was in my early 20’s I worked in a grocery store, and eventually I found myself behind the register. The ergonomics just didn’t favor lefties, so I learned 10-key right handed. I scanned with my left and ran the register with my right, and I was very fast using both hands in concert! Now, 30 years later, working in IT, I still use the right hand for 10-key and the mouse way better than I ever could left handed. And, if I need to pickup my pen or pencil, my left hand is free to do so. Training does have an impact.
As far as my bass journey, which started a mere 18 months ago, I find that the fretboard is the most challenging aspect of learning bass. I really thought it would be a breeze, but it wasn’t. The right hand has been fine, although one of these days I’ll pick up a pick…and maybe I’ll sing a different tune! When I pick up a guitar, my right hand feels like all thumbs with the pick in hand. Training needed, we’ll see.
I really like the fact that @JoshFossgreen is left handed, and look at what he’s been able to do. I don’t think I’ve ever hear him speak specifically about this topic in detail.
Nevertheless, I think it’s cool to play left handed, adds a certain symmetry to gigs!