we had this post for general information about alternate tunings : Alternate tuning
I (re)built a bass for BEAD tuning. I used the 4 biggest strings of a 5-strings set. I had to make a new nut, and I had to modify a little bit the bridge and the “B” saddle to allow the biggest string to fit.
otherwise it should be fine, of course you will have to adjust the saddles and check the truss rod but that’s no big deal.