I use it standalone in my experiments so far. So I’m not connected to the computer via Rocksmith realtone cable or a DAI- I just play along as if it were really fancy sheet music.
At some point I’ll try connecting - but I don’t think it would have rocksmith style “gameplay” where it detects your notes. I think it would just allow you to record your own track as you play along - and easily turn that on or off in the master song file.