I know this thread has some age. but I thought i would put some info in here as well. Just incase anyone’s wondering.
You can flip the strings to be tab accurate if you do not like the set up they use at base.
You can play with a 4 string. 6 string. probably even a 3 string if your up for the arm workout. The only thing the game cares about is note accuracy. for instance on my 6 string, instead of having to de-tune for drop D all of the time for heavier songs. I can just use the 3rd Fret D on my B string, and skip to my E string for anything higher. and it registers just the same. (also good for learning how 4’th etc. work.
There is also a really good mod out now for those that don’t know that will allow you to use Custom forge songs created by note trackers, and another that allows you to plug and play with any 1/4 jack to USB on the market directly or through an amp so you can hear yourself more clearly with out all of the effects the game likes to push onto you. among tons of other great features.
Currently I’ve got a library of about 600 songs, and id say 550 of them are at 98% or more. So its not really difficult once you get it worked out and learn your fretboard. It is a lot of fun and good exercise I find for keeping your hands worked out and learning to relax them. As well as having a chance to hear the band play along with you and get into a good groove. The best part of it all is you can make up basslines as you go and there is really no penalty for it. witch is a lot of fun for experimenting.
Defiantly not a replacement for the wealth of knowledge Josh is sharing with us all though. but at least a good jam session emulator.
(Links to the mods for the people interested)
GLHF